According to the founder of the International Research Pain Federation, the famous paintor research pioneer, US anesthesiologist John Bonka estimates, nearly one-third of Americans suffer from persistent and periodic pain. To this end, the time and cost of the United States in this area far exceeds cancer and heart disease. How is pain in the end? I have been confused for a long time. Later, scientists had repeated trials and explore, and some theories have been made to make people have a preliminary understanding. Scientists headed by John Bonka, is based on the chemical principle of the human nervous system: After a certain part of the human body, some chemicals will be released immediately, while generating pain signals. The released chemical is mainly: the P material, prostaglandin, and latexinin used to pass the pain signal. Delayernotin is a substance that acts on plasma spherulopathy by trypsin, contains nine amino acid chains, which is most intense in known pain substances. P material, prostaglandin and latexinin, will stimulate the nerve endings, so that the pain signal is passed from the injured part to the brain. Prostaglandin can also accelerate the blood circulation of the injured site, enabling a large number of anti-infective white blood cells in the affected area, causing local redness. Bonka believes that painkilles containing aspirin's drugs and heat-saving pains can reduce pain because they can inhibit the production of human prostaglandins. Clinically, he often uses these analgesics to treat pain. However, Bonka's theory is unable to explain some of the phenomenon of disintegration. Dr. Charles Poleti, the Department of Neurology, Medical Department, Massachusetts, USA, recalls one thing when you are young: a winter night, and his girlfriend in love is outdoors. They sat on the stone chair and talked very speculation, forgot time and cold. Finally, they stood up and prepared to go home, and this felt that the hips had difficulty pain. Poleti said: "I almost frozen. We must sit there for a long time, and I didn't feel anything. My nervous system has some kind of substance inhibiting that kind of pain." In real life, similar examples are all. Medical Professor Henry Bechcher, a medical professor of Harvard University, has made a sampling statistics. It was found that two-thirds of the wounded from the battlefield did not feel pain during the injury, and even did not have pain in a few hours after injury. In the wilderness hospital, they will not be able to accept surgery. The civilians sent to the ambulance station are always embarrassed, yell, especially women, only one-fifth person does not shout. In 1965, two experts who were engaged in pain research: Patrick, London, Wall and Canada, Macillzak, Canada. Gate control theory is proposed. This theory believes that in any case, the nervous system can only handle a certain amount of sensory signal. When the sensory signal exceeds a certain limit, some of the cells in the spinal cord automatically suppress these signals, as if the gate is the same, to refuse them outside the door. At this time, the pain signal is not easy to get through the gate, so the feeling of pain will alleviate. Gate control theory makes Poleti's young pain to reduce the mystery of the mystery. But what is the substance inhibiting pain in the nervous system mentioned in Pletti? In 1975, the Pharmacist John Houhes and Hans Kostelet, the University of Scotland finally determined that this substance called endorphin, which is a strong inhibition of pain in the brain and spinal cord. Active substance. However, the test did not terminate this. With the cooperation of the Scottish research team, the University of California's hormone expert West Enli, separated from the human brain, from 40 to 100 times the endorphine of the endorphin.
