Professor of China's Youth Trauma Surgery, Director of the People's Liberation Army 304 Hospital Trauma Research Office, etc. The cells have inverse differentiation. The major discovery of this cell biology is of great significance to revealing the mystery and trauma, refractory skin diseases, etc. Epithelial cells are the most active metabolism of human body, and is also one of the most vulnerable important organs. For a long time, people have been looking for methods that make people cells from aging to the young inverse differentiation, but never found clinical phenomena, and did not find exact laboratory evidence. Since the mid-1990s, under the guidance of Sheng Zhiyong, Wang Zhengguo, which is famous in China, Wang Zhengguo, etc. Clinical phenomena that cannot be interpreted by traditional repair theory, such as why the wound can be quickly repaired under a very small amount of growth factor; the skin of the growth factor is applied, why is some epidermis to become "old". The discovery and preliminary confirmation of epidermal cell reverse division, providing theoretical basis for people's long-term pursuit of tissue cells "return to the older children". It is not only an important discovery of cell biology, but also has important significance for in-depth clarification mechanisms. At the same time, this particular phenomenon that is reversed by differentiated epidermal cells into epidermal stem cells has potentially important for treatment, such as using residual epidermal stem cell regeneration skin sweat gland and hair follicles, treating certain refractory skin diseases.